i&i Prague, the Technical University of Liberec, and the Faculty of Medicine of Charles University in Pilsen will support the technology for the prevention of complications in intestinal surgery

Prague, Czech Republic — October 1, 2025 — The i&i Prague biotechnology incubator, the Technical University of Liberec, and the Faculty of Medicine of Charles University in Pilsen have signed an incubation agreement to support the commercialization of the Nanoflexion project, an advanced medical nanotechnology aimed at reducing postoperative complications in gastrointestinal surgery. This agreement represents an important milestone in the journey of this technology from research to clinical practice.

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The Nanoflexion technology, which was developed through interdisciplinary collaboration between material engineers and medical scientists, uses nanofiber materials to overcome long-standing problems in colorectal surgery. "Nanoflexion was born out of an urgent need to prevent serious post-surgical complications that have been troubling patients for decades. This agreement gives us the institutional backing and support we need to translate years of research into clinical reality," said Markéta Hujerová (Klíčová), founder of the Nanoflexion project, who recently presented the project at the World Expo in Osaka, Japan.

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The technology is based on the application of patches that use electrostatically spun nanofibers to create a tissue-friendly protective layer around the surgical site. The patch is applied directly during surgery, where it serves as a protective barrier on the intestinal anastomosis and helps prevent adhesions and leakage of intestinal contents. The project is currently in the preclinical development phase with the aim of initiating the first clinical trials.

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Comprehensive innovation ecosystem

Under the signed agreement, i&i Prague will provide incubation support in the form of expert advice on scientific, legal, commercial, and other issues, while the Technical University of Liberec and the Faculty of Medicine in Pilsen will participate in research and preclinical verification of the technology.

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"At i&i Prague, we focus on supporting breakthrough innovations that can fundamentally improve patient care. Nanoflexion fits perfectly into our vision of supporting scalable and beneficial technologies," said Roberto Fernandez Alvarez, incubation manager at i&i Prague.

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“The Technical University of Liberec is the cradle of industrial nanofiber production, thanks to the patented technology for producing nanofibers by electrostatic spinning – Nanospider®, which was introduced to the world in 2004 by the team of Professor Oldřich Jirsák from the Faculty of Textile Engineering at TUL. Over the past twenty years, researchers from our university have registered 170 patents, more than 20 of which are in the field of nanofiber production. Nanoflexion is another scientific and research success in the field of nanofibers, which was born in cooperation with other partners, primarily clinical doctors from the Faculty of Medicine at the University of Pilsen, in Liberec," said Petr Lenfeld, Vice-Rector for Science and Research at the Technical University of Liberec.

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"From the perspective of the medical faculty, we see great potential in Nanoflexion technology for reducing postoperative complications in colorectal surgery. We are happy to contribute our experience in its preclinical and future clinical testing," added Prof. MUDr. Václav Liška, Ph.D., from the Faculty of Medicine at Charles University in Pilsen.

 

Contact for journalists:

Markéta Hujerová (Klíčová), marketa.hujerova@tul.cz, +420 731 231 434
Martin Kovalčík, kovalcik@iniprague.com, +420 777 472 863

 

About the Nanoflexion project

Nanoflexion is a MedTech innovation project focused on preventing serious complications during gastrointestinal surgery using biocompatible nanofiber patches. The technology is the result of more than seven years of interdisciplinary research.

For more information, visit www.nanoflexion.eu.

 

About i&i Prague

i&i Prague is a biotechnology incubator and venture builder founded in 2017 at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences. The company is dedicated to innovation in the field of drug development, diagnostics, and medical technologies, specializing in supporting startups and spin-offs in the early stages of their development. i&i Prague provides expert advice on scientific, legal, business, and other issues that need to be resolved in order for new companies to grow successfully. It creates a unique network of startups, investors, industry partners, and biotechnology experts, enabling effective collaboration and knowledge sharing.

For more information, visit www.iniprague.com.

 

About the Technical University of Liberec

It is a public university that was founded in 1953. The university has 7,000 students enrolled in seven faculties. TUL also includes the research Institute for Nanomaterials, Advanced Technologies and Innovation (CXI). TUL is the cradle of industrial-scale nanofiber production. The current QS ranking places TUL among the 1,000 best universities in the world in the 801–1,000 range. In THE World University Rankings, TUL ranks 1,501+. According to a study by the IDEA think tank at the National Economic Institute of the Czech Academy of Sciences, TUL ranks fifth among Czech institutions, research centers, and companies with the most cited patents, and first among universities in the Czech Republic.

For more information, visit www.tul.cz. 
 

About the Faculty of Medicine in Pilsen, Charles University

The Faculty of Medicine in Pilsen is an important center of medical education and research. It is the only representative of Charles University in the West Bohemian region.  The faculty educates graduates who acquire a broad education, knowledge, and basic practical skills in all theoretical, preclinical, and clinical fields of medicine. It carries out scientific and research activities at an international level, creates a creative academic environment, and supports internationalization in both student teaching and scientific activities.

For more information, visit www.lfp.cuni.cz.