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Earlier News We help inventions grow! 2021-2022 Interview with Jaromír Zahrádka: Investments help science to serve people Read more The judges at Transfera Technology Day 2021 awarded the cream of the crop Read more i&i Prague supports the innovative PEP-Therapy in their extension of the Series-A ... Read more Enantis concluded a license agreement for the production of stabilised growth factor FGF2 Read more PerioTrap Pharmaceuticals Raises €3M Seed Round to Develop Selective ... Read more Elphogene received a TA CR grant for “Sample prep system and technology for cancer ..." Read more Our notes from a trip to “The most startup friendly country in the whole world” Read more Spin-off CasInvent Pharma receives the Neuron Award for excellent Technology Transfer Read more Licensing agreement for a novel SARS Cov-2 virus neutralization antibody test was signed Read more i&i Prague supported LAM-X a.s. won the 2020 EIT Health MedTech Bootcamp final ... Read more UCT Prague entered in memorandum with i&i Prague, s.r.o. Read more i&i Prague announces its first exit, DIANA Biotechnologies is bought out by its founders Read more i&i Bio, the newly estabilished investment fund powered by i&i Prague and EIF Read more Green chemistry start-up Sulfotools closes seed round with i&i Prague Read more CasInvent Pharma, an University Spin-Off Focused on Developing Cancer Drugs... Read more Dracen Announces the Initiation of First-in-human Study of DRP-104 in Adult Patients With ... Read more 2020-2018 Nanofibers from Technical University of Liberec brings new hope in fight against Covid-19 Read more Enantis – first biotechnology spin-off from Masaryk University in Brno Read more DIANA Biotechnologies – technology that raised EUR 3M in 3 years Read more License for use of iBodies® bought by Immunotech, a member of the Beckman... Read more LAM-X: revolutionary wound-treating nanomaterials Read more Elphogene – liquid biopsy assay for non-invasive monitoring of patients with colorectal cancer Read more Novel partnership for iBodies has been facilitated by i&i Prague and IOCB Tech... Read more i&i Prague became a shareholder in the spin-off XENO Cell Innovations! Read more i&i Prague successfully mediated an out-licensing of antibodies from IMG Read more LAM-X – light-activated nanomaterials for face-masks and respirators Read more Elphogene: non-invasive screening of patients in advanced stages of cancer Read more DRACEN Pharmaceuticals – Novel glutamine antagonist as anticancer therapies Read more iBodies – synthetic antibodies from Institute of Organic Chemistry and Biochemistry Read more Elphogene in World Journal of Gastroenterology! Read more A novel early cancer diagnostics method has been developed at University of Pardubice,... Read more Revolutionary type of catheter raised €2 million from private investors Read more i&i Prague co-invested Dracen Pharmaceuticals, a company developing a novel oncology... Read more Prague startup RIOCATH had recently entered market with its world-unique catheter! Read more Czech anti-covid19 #hackathon won by two i&i Prague accelerated projects Read more LAM-X a.s. is collaborating with TUL to develop active nanofilters against COVID-19 Read more iBodies established cooperation with Ximbio, a TTO within the UK’s largest charity... Read more LAM-X: the spin-off accelerated by i&i Prague in Media Read more DIANA Biotechnologies, a novel startup in the i&i Prague´s academic incubator Read more Startup Riocath is among Hello Tomorrow’s top 500 stratups in the world Read more i&i Prague is joining Hello Tomorrow Ecosystem, a global community boosting deep... Read more

The judges at Transfera Technology Day 2021 awarded the cream of the crop This year at the 2nd Transfera Technology Day, the first place went to the Tablets for the Treatment of Contaminated Water. The second place was taken by the Microemulsions and Gels for Cleaning Surfaces of Historical Materials and the bronze went to the project aimed at detecting bacteria in amniotic fluid. The jury consisting of representatives of the business community, investors and organisers assessed the commercial potential of research projects of Czech universities and other research institutions. This year, they also awarded the Sympathy Prize for the first time – it went to the special oxygenation liners for fishing beads. The event aims at connecting science and business in order to get valuable feedback regarding the commercial potential of projects and secure future funding for promising research projects. “Czech science and research has many talented people to offer. However, they need to be supported and motivated. That’s why we’re glad we can keep connecting the world of business with the great ideas of our scientists. Especially at its start, no project can survive without support,” says Eva Janouškovcová, chairwoman of the Transfera.cz association, the co-organizer of the event. Battle of Universities, Research Institutes and Hospitals 13 scientific research projects were selected as finalists (aside from the first three projects, there were e.g. the Electrostatic Separation of Plastics to Improve Wate Separation, the Pad for Sensing the Load and Position of the Patient or the Device for Coating Wires in Implant Surgery). There were teams of scientists from the Czech Technical University in Prague, the National Institute of Mental Health, J. Heyrovský Institute of Physical Chemistry, the University of West Bohemia, Palacký University Olomouc, The University of Hradec Králové, Brno University of Technology, University Hospital Hradec Králové, VSB – Technical University of Ostrava, Masaryk University, the Institute of Rock Structure and Mechanics CAS, the Institute of Geonics CAS and the University of South Bohemia in České Budějovice. The jury chose the best three out of these teams. The winning project of the Palacký University Olomouc is meant to be used mainly in case of natural disasters or industrial accidents. The new effervescent tablets for the treatment of contaminated water are easy to store and use – you simply put them in the contaminated water. Thanks to being “fizzy”, they take effect very quickly. The tablet dissolves completely in just 30 seconds allowing the active ingredient to perform its function. Moreover, they do not contain any toxic substances and are environmentally friendly. The second place went to the Microemulsions and Gels for Cleaning Surfaces of Historical Materials developed by the team of J. Heyrovský Institute of Physical Chemistry CAS. These extremely gentle yet effective microemulsion cleaning systems are designed to remove unwanted substances from various valuable historical artefacts. The main component here is water – the content of the active ingredients is very low, yet they are highly effective. The third place went to the University Hospital Hradec Králové and their project Detection of Bacteria in Amniotic Fluid in Patients with Preterm Prelabour Rupture of Membranes. This new method helps detect the presence of specific bacteria in amniotic water in just a couple of hours. Thanks to this, it will be possible to initiate effective antibiotic treatment in time and reduce the adverse effects on the fetus. Sympathy Prize Will Help Fish The Sympathy prize was won by the Aeration and Oxygenation Liner in Fishing Beads from the University of South Bohemia in České Budějovic. This liner should improve the conditions of the fish stored in beads e.g. when fishing out ponds or during pre-Christmas sales. The new liner will provide sufficient oxygenation of water without the necessity of weighting down the aeration hoses, which complicates catching the fish and often results in injuring them. Winners Got Both Money and Well-deserved Attention The projects that made it to the finals can use the title Finalist of TRANSFERA TECHNOLOGY DAY 2021. The winning project was awarded the title Winner of TRANSFERA TECHNOLOGY DAY 2021. The certificate is a mark of quality and can help secure not only financial support. The finalists will also receive an invitation to the Technological Incubation project of the CzechInvest agency who can allocate funding of up to CZK 5 million to each project. The jury that evaluated both the presentations and the commercial potential of the projects consisted of the representatives of investors and other experts – Petra Gordan (Nation1), Jaromír Zahrádka and Barbora Šumová (i&i Biotech Fund), Jakub Domitra (Busyman), Eva Janouškovcová and Petr Kubečka (Transfera.cz), Jiří Krechl (CzechInvest), Robert Reich (Lighthouse Ventures) and Václav Novák and Jaroslav Řasa (NEURON Endowment Fund). The competition has been organized by Transfera.cz together with its general partner CzechInvest and other partners (e.g. Technology Agency of the Czech Republic, NEURON Endowment Fund, vedavyzkum.cz and others). A record of the event can be found at www.transfera.cz .

i&i Prague supports the innovative start-up PEP-Therapy in their extension of the Series-A financing, totalling €5.4 million to progress the clinical development of the lead candidate PEP-010 PEP-Therapy, a biotechnology company developing cell penetrating peptides as targeted therapies for the treatment of cancers, announced today that it raised an additional €2.6 million ($3 million) in an extension of its Series A financing round, bringing the total raised in this round to €5.4 million ($6.4 million). This new funding comprises €1.6 million in equity from Anaxago, i&i Prague and BADGE as well as a €1 million loan from Bpifrance. This increased financial support highlights the potential of PEP-010, as well as PEP-Therapy’s Cell Penetrating & Interfering Peptide (CP&IP) technology platform, which was first developed at Sorbonne University and Institut Curie. PEP-010 is the first of a new class of therapeutic peptides based on PEP-Therapy’s innovative Cell Penetrating & Interfering Peptide (CP&IP) technology. These innovative molecules penetrate cells and specifically block relevant intracellular protein-protein interactions, leading to the inhibition of key pathological mechanisms, without altering physiological mechanisms. PEP-Therapy will use the funds to finance the Phase I a/b clinical trial of PEP-010, PEP-Therapy’s lead candidate, for the treatment of advanced solid tumors. The first part of the Series A, which closed in April 2021, will finance the Phase Ia dose escalation part of the study, with the additional funds being used for the development of PEP-010 until the end of the expansion cohorts, Phase Ib. PEP-Therapy expects to generate promising clinical data from this study, particularly in two indications: metastatic triple negative breast cancer and platinum resistant ovarian cancer. Patients with these two types of solid tumors have a poor prognosis and limited therapeutic alternatives. Antoine Prestat, CEO and co-founder of PEP-Therapy, said: “We are delighted to have completed this financing round via an attractive balance of dilutive and non-dilutive funds from new high quality and diversified investors who will bring expertise and new insights to support our development.” Jaromír Zahrádka, PhD, CEO of i&i, commented: “PEP-Therapy has developed an extensive knowledge of targeted peptides and the promising preclinical data the company has generated show great potential. We are looking forward to seeing the confirmation of the positive results seen in preclinical data in the upcoming Phase I study.” Gaston Vasseur, Investment Manager at Anaxago, added “This extended financing highlights PEPTherapy’s capacity to attract highly specialized as well as diversified investors. The Company has managed to rapidly secure the funding for the Phase I trial with PEP-010, a very important milestone for the company. We are happy to contribute to this financing round in conjunction with a number of experienced life science investors.” In addition, PEP-Therapy and its clinical partners, Institut Curie and Gustave Roussy, previously received a €2.9 million grant from the French state innovation fund – Fonds Unique Interministériel (FUI) – to finance nonclinical and early clinical development of PEP-010. About Anaxago Founded in 2012, Anaxago Venture Capital is a digital VC firm specialised in Healthtech & Biotech, Proptech, Fintech and Impact investing. Anaxago Venture Capital has financed more than 45 companies since its creation. About BADGE Business Angels des Grandes Ecoles (BADGE), created in 2004, is a leading French Business Angels association with more than 280 members, and having participated in 21 fundraisings in 2020 of a combined value of over €5.3 million. Its members are recognized leaders in all sectors of the industry and are willing to finance and support young innovative companies with high growth potential. BADG aims to: Identify and review promising innovative projects Conduct fund-raising for the most promising ones Support the entrepreneurs with individualized business advice and key contacts Provide training and methodological support to its members BADGE has thus financed more than 185 young companies since its creation.

From the Lab to the Market: What Biotech Commercialization Looks Like from the Perspective of an Incubator How does starting a company developing a new drug differ from, for example, one focused on IT? What can convince an investor to join such a company? Why should a scientist embark on the commercialization of their discoveries? What is the paradoxical advantage of being behind the global biotech leaders in the Czech Republic? And why do you sometimes feel like a translator? Jiří Moos, director of the biotech incubator i&i Prague, answers all these questions and much more in the following interview. Your incubator specializes in biotechnology. Could you first outline the specific characteristics associated with this field? There are indeed many differences compared to other areas of business. For example, I would mention the speed of revenue generation. In other industries, this is a key criterion for assessing the value of a project. However, in the development of new drugs, this question doesn't make sense. The project is meant to be sold to a pharmaceutical company while it's still far from commercial success. The value of these projects is therefore assessed based on entirely different criteria. Other specifics involve meeting strict regulatory conditions that ensure the safety and efficacy of the developed products, medical devices, or in vitro diagnostics. Therefore, we sometimes advise our startups to consider collaborating with an industry partner experienced in regulatory processes. This can save a lot of time and money. The same applies to distribution channels, which cannot be built overnight. Also worth mentioning are the higher initial investments required for equipping a top-notch laboratory. i&i Prague supports scientific startups in the early stages of their development. Could you describe how this process works? The first step is market need analysis. We examine whether the technology solves a problem that is currently unresolved. If so, we then assess the uniqueness and the possibility of intellectual property protection. Next comes the agreement with the originators of the technology on commercialization. There are two options – we either offer it for direct licensing, or we decide to establish a startup, which will secure investment and bring the development to the point where the technology is either commercially viable or saleable to a strategic partner. If the decision is made to go with a startup, which is your area of expertise, what needs to be done to convince an investor? Without an investor, the startup will not last long. That’s true. For a startup to secure initial investment, it must demonstrate that it has a technology aimed at a product with market potential – something that people or companies will be willing to pay for. If a startup is developing medical technology, it should seek feedback from doctors and, if possible, from a relevant industry contact. This market validation should occur early, before more extensive development begins, to avoid unnecessary dead ends. Investors also focus on intellectual property protection, which must be secured so that competitors cannot easily take over the technology. The startup team is also crucial – the members must be fully committed to the project and have the necessary skills. And, of course, the quality of the business plan is important to investors as well. From what you've said so far, it seems like a very demanding and sophisticated process. Why should a young scientist even go down this path? There are two main motivations. The first is humanitarian – science should help people and society. The results of scientific work, if they remain solely in the realm of academic science, can inspire further research but will not help anyone in a real way until they reach the market as actual products. The second motivation is experience. Working in a startup provides people with invaluable knowledge that continuously moves them forward. In Germany or Austria, these individuals are among the most valuable on the job market. You often work abroad. Can you describe how we are doing in this area compared to the developed world? It probably won’t surprise anyone that we are behind countries like Germany, Austria, Israel, or the USA. However, this lag can paradoxically be an advantage because we have the opportunity to be inspired by different systems. While it's not possible to take only the best from each country and create something entirely our own, we have a chance to create a thoughtful system that avoids the mistakes of others. What would you personally bring to the Czech Republic? There are really many insights, but I would especially mention two: the approach to problems and the willingness to collaborate. In Scandinavia or Israel, the approach to business and innovation is much more positive. It would be great if we could also learn to see problems as challenges to overcome and have the State here to help, not to place obstacles. In the scientific world here, unfortunately, business is still often seen as a betrayal of science, which needs to change. Additionally, it’s essential that scientists are willing to listen and be open to collaboration with experts from other fields. What is needed to successfully connect these different worlds? It’s about understanding the different mindsets. For example, aligning expectations regarding transparency and intellectual property protection. Academic institutions have an obligation to disclose contracts and publish results, which may conflict with the caution and need for strict intellectual property protection in the business world. Long-term stability of cooperation is also important, which can sometimes be a challenge in dynamically changing teams. Properly setting up relationships and achieving balance is not easy, but it’s essential for successful collaboration. How can this be achieved? That is one of the tasks for companies like ours. Sometimes I jokingly say that working in our incubator requires not only a scientific and business background but also translator skills to ensure proper communication between the academic community and industry. Author: Martin Kovalčík

OUR TEAM Our team benefits from decades of know-how and experiences gathered in academic institutions, technology transfer and industrial companies. Using this knowledge, we are developing a pool of highly potent biotech projects originating in academia and finding commercial partners for them. DAVID STÍBAL CEO David evaluates the business potential of scientific projects, establishes and initially manages startups, and works on the long-term development of projects all the way to their successful commercialization. David completed his bachelor’s and master’s degrees at the University of Chemistry and Technology in Prague, earned a Ph.D. from the University of Neuchâtel in Switzerland, and conducted postdoctoral research at the prestigious Massachusetts Institute of Technology (MIT). Prior to joining us, he worked in Lach-Ner s.r.o. as a research scientist. LinkedIn Mail JIŘÍ MOOS Managing Director In addition to managing i&i Prague, Jiří is responsible for project analysis. He is a member of the GAMA Commercialization Council of the Institute of Molecular Genetics (IMG) and an external member of the Supervisory Board of the Institute of Biotechnology. Previously, he was a senior sales manager at Sigma-Aldrich and coordinator of regional activities of the Sigma-Aldrich Applied Business Unit. He also worked at Immunotech a.s. and has extensive experience as a researcher at the Centre for Assisted Reproduction at the General University Hospital in Prague and IMG. LinkedIn Mail ROBERTO FERNANDEZ Lead Incubation Manager Roberto is responsible for the analysis of projects. Prior to joining us, Roberto completed his Ph.D. in Macromolecular Chemistry at Charles University in Prague. He holds a BSc in Chemistry from the University of Costa Rica and an MSc in Biochemistry and Biotechnology from Autonomous University of Barcelona. Parallel to his work in i&i Prague, Roberto works as a project manager in the MedTech start-up LAM-X a.s. Due to his experience, Roberto prefers to focus on projects in the field of medical devices and drug delivery. LinkedIn Mail IVA MACHOVÁ Incubation and Regional Manager for Poland Iva is responsible for the analysis of project technology. Before joining our company, Iva worked as a postdoc researcher at the Biomedical Center of the Faculty of Medicine in Pilsen. She holds BSc and MSc degrees from UCT Prague, Czech Republic, and she did her Ph.D. at the Institute of organic chemistry and biochemistry. Iva spent several months on a postdoctoral fellowship at Ludwig-Maximilians-Universität München. Due to her scientific experience in biochemistry, she is focused on projects in the field of drug discovery and cell therapy. LinkedIn Mail JIŘÍ RŮŽIČKA Incubation Manager Jiri is responsible for analyzing projects at i&i Prague. He also worked at the Institute of Experimental Medicine of the CAS (IEM), the University of Cambridge, and the University of Leeds. He has done his PhD at IEM and the 2nd Faculty of Medicine of Charles University. He has 14+ years of experience in neuroscience and regenerative medicine with a broad focus on brain/spinal cord injuries, neurodegenerative diseases, and ageing. He has been dealing with enzymatic, gene, or cell therapies, biomaterial applications, and genetic models of neurodegenerative disorders. Mail Mail KAMILA BURDOVÁ Incubation Manager Kamila is an Incubation Manager at i&i Prague. She brings over a decade of scientific experience in molecular biology, genome stability, and DNA repair, gained at leading research institutions including the Institute of Molecular Genetics in Prague, the University of Oxford, and the University of Sussex. At i&i Prague, she supports the development and growth of early-stage biotech projects with strong scientific foundations. Her deep understanding of academic research allows her to bridge the gap between science and commercialization effectively. LinkedIn Mail JAN BERKA Project Manager with a Focus on International Contacts Jan studied molecular biology and genetics at Masaryk University in Brno (Czech Republic). After his doctorate, he worked at the Barnett Institute, Northeastern University in Boston on the development of DNA sequencers. Later, he worked at CuraGen, 454 Life Sciences, Pfizer Rinat and Adaptive Biotechnologies, where he was involved in pioneering methods of DNA and immune system sequencing. Before joining i&i Prague, he worked at Roche Molecular Diagnostics in California, developing biomarker assays. Mail Mail SIMONA ŠANDOVÁ Office Manager Simona is responsible for making sure that everything works as it should in i&i Prague. During her career, Simona has worked as an Office Manager and a Junior Property Manager. She was responsible for training and conference organization, communication with clients and suppliers as well as administrative assistance for the project and property department. Simona has considerable experience in administration and office management. LinkedIn Mail MARTIN KOVALČÍK Communication Manager Martin is responsible for PR activities and communication of our incubator. Prior to joining i&i Prague, Martin worked for nearly 13 years as a media coordinator at the respected Czech non-profit organisation, People in Need, where he was responsible for regular media relations and media service for a team of 300 people. He also has experience working in several editorial offices. He left his most significant mark at the Metro newspaper, where he worked for over 5 years, the last two as the deputy editor-in-chief. Mail Mail

Neuron 2024 Award for Bridging Science and Business Goes to SophoMer, s.r.o., a Startup from i&i Prague's Portfolio A team of scientists from the Institute of Macromolecular Chemistry of the Czech Academy of Sciences (IMC CAS), together with representatives from the startup SophoMer s.r.o., the i&i Prague incubator, and ELISA development, received the prestigious Neuron 2024 Award for Bridging Science and Business. The awards ceremony took place on Sunday, January 19, at the National Museum in Prague in the presence of the President of the Czech Republic, Petr Pavel. What Is SophoMer™ and Why Is It Groundbreaking? Reliable results in immunodiagnostic in vitro tests have traditionally relied on animal-derived proteins, such as bovine serum albumin (BSA). However, BSA does not meet the standards for Animal Component-Free (ACF) materials, which are required to contain no animal-origin components. Additionally, BSA exhibits inconsistent properties and poses a risk of pathogen transmission. These issues are resolved with the synthetic molecule SophoMer™ F10. This polymeric material eliminates the risks associated with animal-derived products and enhances the stability and performance of diagnostic tests. According to Tomáš Etrych, Head of the Biomedical Polymers Department at IMC CAS, “The collaboration between our team and SophoMer is highly beneficial for both parties, and we are thrilled that the Neuron Foundation has recognized this bridge between science and business. We believe this award will serve as an important stimulus for our future collaboration.” From Lab to Market SophoMer s.r.o. was founded in 2022 and signed a licensing agreement with IMC CAS, ELISA development, and i&i Prague in January 2023. Just two months later, the SophoMer™ F10 material was sent to customers for testing. What sets SophoMer apart is its early focus on industrial applications, addressing a clear market need from the outset. “We are validating our first polymer by co-developing diagnostic kits with the Brno-based company BioVendor, where our product, SophoMer™ F10, is used as a standard component in the kits. These valuable experiences are then applied at i&i Prague when preparing incubation plans for other projects,” explains Jiří Moos, who, along with Jan Plicka, initiated the project. Currently, four diagnostic kits are in development, with one set to hit the market soon. “In addition, we have already defined a new portfolio of innovative polymers on which we are working intensively,” notes Martin Burkhard, CEO of SophoMer s.r.o. Awards Ceremony The Neuron 2024 Award for Bridging Science and Business was received on behalf of IMC CAS by Dr. Tomáš Etrych, Head of the Biomedical Polymers Department, along with his colleagues Libor Kostka and Vladimír Šubr. SophoMer s.r.o. was represented by its CEO, Martin Burkhard, while i&i Prague was represented by its CEO, Jiří Moos, and ELISA development by Jan Plicka. SophoMer™ F10: How does it work?

The Prague.bio international conference will bring together the best of science and business in Prague. Promising ideas will receive money for their development. Prague, 25 April 2023. The first edition of the Prague.bio international conference will offer a unique meeting of representatives from science and business who will exchange their experiences in the development of new drugs, diagnostics, medical technologies and other areas of biotechnology. The event is supported by the Czech government and will feature renowned experts from the world of BioTech. The Prague.bio international conference is intended for academics, investors and industry representatives from all over Central Europe. Experienced investors, representatives of leading pharmaceutical as well as diagnostic companies and technology transfer offices will meet promising startups, scientists and students to help them with advice and insights in commercializing their scientific ideas. For industry representatives and investors, the conference will provide an interesting space for exchanging ideas and establishing further cooperation. "Science and business are often two completely different worlds. But they need each other and have something to offer each other. Scientific projects are often a source of unique commercial ideas and an interesting investment opportunity, while successful commercialisation of scientific knowledge brings significant financial resources back into research," explains Prof. Martin Fusek, Director of IOCB Tech, one of the organisers of the conference. According to him, the Prague.bio conference should contribute to the creation of a permanent network of partners whose goal will be to build a more effective transfer of biotechnology not only in the Czech Republic but also in the entire Central European area. The transfer is also supported by the government "Who does not transfer is not a good economist. The transfer of scientific research knowledge into practice is one of the priorities of our government and I am pleased that a conference is being prepared to help this even on an international scale," explains Helena Langšádlová, Minister for Science, Research and Innovation of the Czech Republic, whose department is co-organizing the event. Moreover, according to the Minister, technology transfer is an important topic not only for science but also for the national economy. It can generate billions of Czech crowns in revenue annually. The Prague conference is based on the experience of similar events abroad. However, it is unique in Central Europe. "At the moment, we can reveal that the Prague.bio conference will not lack lectures by representatives of major pharmaceutical companies, we are also preparing an interesting panel discussion with foreign investors and several pitch sessions that will provide an opportunity to present promising projects in the field of biotechnology," adds Jaromír Zahrádka, CEO of the i&i Biotech Fund and founder of the i&i Prague bio-innovation centre, another of the conference organisers. The conference will take place on 26 September at Liechtenstein Palace in Prague. Registration is now open for those interested in attending. The relevant form, including payment options, can be found at www.prague.bio . The fee for early registration is 200 Euros, or 150 Euros for students and researchers. Interesting scientific research ideas can also apply for the event and register at the above-mentioned website. The registered projects will be evaluated by an expert committee and the best ones will compete for investor support at the conference. Contact Martin Kovalčík, 777 472 863, kovalcik@iniprague.com Martin Opatrný, 602 252 405, opatrny@prclinic.eu About IOCB Tech The Technology Transfer Office IOCB Tech, s.r.o. is a fully owned subsidiary of the Institute of Organic Chemistry and Biochemistry (IOCB). The main responsibilities of IOCB Tech include the identification of commercially interesting projects at IOCB, analysis of their market potential and patentability, protection of intellectual property, support for the development of the projects in the form of project management, search for commercial partners and negotiation of contractual terms for signing license agreements. IOCB Tech has been involved in the process of negotiating and concluding more than a dozen key license agreements with major pharmaceutical partners such as Gilead Sciences, Merck, Novo Nordisk and SHINE Medical Technologies. In 2017, the company established a subsidiary, i&i Prague, which focuses on funding promising early-stage projects at the Institute and other research and academic institutions. For more information visit www.iocbtech.cz . About i&i Prague The i&i Prague Bio-Innovation Center focuses on the transfer of new technologies into practice. The company was established at the Institute of Organic Chemistry and Biochemistry of the CAS and is mainly dedicated to innovations in the field of drug development, diagnostics and medical devices originating from academic institutions. It supports the creation of spin-off companies and the sale of licenses. So far, the company has participated in the creation of or otherwise supported 15 spin-off companies from five countries, has an equity stake in nine of them and has invested over 70 million crowns. In total, the spin-offs in i&i Prague's portfolio have raised more than CZK 1.8 billion from other investors. In addition to direct financial investments, i&i Prague also assists more than 15 research institutions and universities in the Czech Republic and abroad in the commercialization of innovative technologies. In 2021, i&i Prague started up the i&i Bio investment fund. About i&i Biotech Fund (i&i Bio) i&i Bio is a Luxembourg-based venture capital firm that invests in innovative European Life Sciences companies focused on drug discoveries, medical devices, diagnostics, and digital health. The Fund was created thanks to the cooperation of the biotech incubator i&i Prague and the European Investment Fund (see below). With over €47M under management, i&i Bio plans to invest in about 20 early-stage companies. i&i Bio is led by an experienced team of professionals with backgrounds in private equity, healthcare and venture capital supporting entrepreneurs on their journey to global success. Thanks to close cooperation with the fund’s main sponsor, the biotech academic incubator i&i Prague, i&i Bio is supporting and advancing transformative Central European technology companies. For more information visit www.inibio.eu . About EIF i&i Bio is supported by an investment from the EIF, with the support of: lnnovFin Equity, with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (EFSI) set up under the Investment Plan for Europe. The purpose of EFSI is to help support financing and implementing productive investments in the European Union and to ensure increased access to financing; and the Pan-European Guarantee Fund (EGF), implemented by the EIF with the financial support of the Participating Member States. The objective of EGF is to respond to the economic impact of the COVID-19 pandemic by ensuring that companies in the Participating Member States have sufficient short-term liquidity available to weather the crisis and are able to continue their growth and development in the medium to long-term.

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Smart bandages not only capture pathogens, but also destroy them in no time. All they need is ordinary light. LAM-X team Hospital-acquired infections are a problem that current technologies are not able to deal with effectively. In the European Union alone they cause around 100,000 deaths each year, with estimates of the costs associated with treatment in the EU around €7 billion per year. However, this could change in the future; the Czech spin-off LAM-X a.s. is working intensively on the development of a nanomaterial that not only passively prevents viruses or bacteria from entering open wounds, but can also actively destroy them. It is made up of nanofibres doped with a photoactive substance which, when activated by ordinary light, eliminates any microbes that are in close proximity to it. Current dressing materials provide a kind of mechanical barrier aimed at suppressing the transmission of infection into the patient's body. However, if the objective is also to destroy the pathogens that cause infections, cover materials containing active silver are available. However, this is potentially toxic to the patient if used for a long time, and over time bacterial strains that may be resistant to this metal emerge. The material from LAM-X a. s. works on a completely different principle. “Our technology works with nanofibres that are hundreds of nanometres in diameter. We use them to create a very dense network that effectively prevents the penetration of pathogens. However, this in itself is not groundbreaking; nanofibre coverings have been produced for some time, although their use is not yet widespread. The added value of our material lies primarily in the fact that we can add a photoactive substance (so-called photosensitizer) to our nanofibres, which, when illuminated with ordinary light, activates a sterilization process that eliminates any bacteria or viruses on the surface of the bandage,” says Roman Chaloupka, CEO of LAM-X a. s. The light-activated photosensitizer can convert virtually ubiquitous molecular oxygen into so-called singlet oxygen, a highly reactive molecule that oxidizes virtually anything that comes in its way. “By using the photooxidation process, we are able to destroy even those pathogens that have already built up resistance to antibiotics or silver. Another huge advantage of our technology is that it eliminates the problem of toxicity of active dressings, which allows their long-term use. The singlet oxygen is generated only on the surface of the nanofibers and, due to its high reactivity, it acts only in close proximity to the nanofibers, so it does not come into contact with the patient's own wound or skin at all. And last but not least, our material is cheaper, as there is no need to use precious metals such as silver in its production,” adds Chaloupka. Bandages, incision films, catheter fixation The development of a second-generation smart bandage with antimicrobial effect is currently moving towards a clinical trial. If its current potential is confirmed, it could help, for example, people with chronic wounds in a few years' time. “More than 50 percent of patients with chronic wounds have been on treatment for more than a year. One reason is that these wounds are repeatedly infected with other bacteria. Our material should prevent this,” says Roman Chaloupka. However, it could be used to treat virtually any wound. A prototype of this type of bandage already exists and is currently being tested preclinically. These are a set of tests that need to be carried out before the product receives the necessary approvals to conduct clinical trials on real patients. Recruitment and follow-up should then take about a year. “By the end of 2024 and the beginning of 2025 at the latest, we should have the data to certify this dressing material as a medical device and subsequently award the CE mark, which is necessary for placing it on the EU market. At that point, production can begin,” adds Roman Chaloupka. However, dressing materials are only one of the paths LAM-X a.s. wants to take in the use of its technology. “At the moment we are already working on the development of other products, because we are convinced that our technology has a much more versatile application. Our material could be used, for example, to drape an operating field, which would greatly reduce the incidence of bacteria that could get close to an open wound. Even better, they could replace incision films, which are glued directly to the patient's skin to enhance health protection, especially in more time-consuming operations. The increase in cleanliness during surgery using our material should clearly reduce the incidence of post-operative infectious complications,” says Roman Chaloupka, outlining further possibilities. The technology of LAM-X a. s. would also find application in intravenous catheterisation, especially in long-term patients. “Even in this case, doctors struggle with the transfer of bacteria into the bloodstream, which causes serious health complications in the form of infections. If we made the adhesive dressings that fix the catheters to the wound from our material, we could largely prevent infections,” explains Roman Chaloupka. Clinical trials, search for an industrial partner LAM-X a.s. was founded in 2020 thanks to the joint efforts of Charles University and the Academy of Sciences. Specifically, its creation is backed by Charles University Innovations Prague, a subsidiary of Charles University, and the i&i Prague bio-innovation centre. It is currently preparing an investment round to raise funds for the aforementioned clinical trials. “All our products fall into the category of medical devices, the production of which is, of course, highly regulated. In order to obtain the necessary permits, whether in the Czech Republic, the European Union or in non-European countries, we need to collect a large amount of data to confirm the safety and efficacy of the material,” explains Roman Chaloupka of the need for clinical trials. The company would like to use part of the funds raised to equip its own laboratory (including a semi-operational nanofibre production facility) and to develop further products using this technology. However, the plans of LAM-X a. s. do not end there. “After completing all the necessary testing of our wound covers, we would like to launch them on the market through an industrial partner in the form of a large multinational company. We are looking for someone who has been involved in the treatment and healing of wounds for a long time, which means they already have a distribution network and effective marketing. We could then continue to focus on what we do best, i.e. on the development of new products,” concludes Roman Chaloupka, CEO of LAM-X a. s. Conclusion The products that LAM-X a.s. develops are based on unique technology that can help improve the quality of life for millions of people. Thanks to their versatility, they can be used in many areas of healthcare. They are also cheaper to produce in many cases than the materials currently used. It is these attributes that give LAM-X the chance to develop its potential not only in the local market, but also to succeed globally.

Jaromír Zahrádka: Investments help science to serve people Jaromír Zahrádka According to Jaromír Zahrádka, director of the i&i Biotech investment fund, investing in science is like the proverbial chicken and egg. If there is a lack of investment, no new projects are created. And without interesting projects, it is impossible to get investors interested. So how to solve this dilemma? Jaromír Zahrádka answers these and other questions in an interview for Vědavýzkum.cz. The fund was established last year and has so far a total of 45 million euros at its disposal. It plans to invest this money over the next five years in about 20 scientific startups, in close cooperation with the i&i Prague incubator and the Institute of Organic Chemistry and Biochemistry of the CAS. Please try to briefly introduce the i&i Biotech Fund. What are you involved in? We focus on investments in unique ideas in the field of drug development, diagnostics and medical technologies. We target early-stage scientific startups that often build on decades of research and have the potential for breakthrough discoveries. We invest to help them at a critical stage of their development. This is the period when they leave their laboratories or research facilities and lose their ability to access traditional sources of funding, such as research grants. At the same time, they are not yet in a position to compete for their first investors. We are trying to help them in their transition from purely scientific projects to functional companies. How does the new fund help? The fund gives us completely new opportunities to do so. And it's certainly not just about increasing the volume of investments we are able to make now. We have added experienced professionals to the team who have a wealth of experience with similar investments, which has significantly expanded our expertise. The fund is also built on standards that are common in Western Europe and the US. It is above all a transparent system with a precisely described investment strategy, clearly defined responsibilities of investors and managers and a precisely defined decision-making system. We want to set a certain standard and thus contribute to the cultivation of the overall environment. It is necessary to move on, because investing in the natural sciences unfortunately does not yet have much of a tradition in our region. The fund was created in cooperation between the i&i Prague incubator and the European Investment Fund (EIF). How was the idea for its establishment born? Let me go back in time. When we founded the i&i Prague incubator five years ago, we wanted to show that there are interesting ideas in the field of life sciences in the Czech Republic that deserve the attention of investors. We have drawn a lot from our close cooperation with the Institute of Organic Chemistry and Biochemistry of the CAS and from the experience of its technology transfer office IOCB Tech, which works well under the leadership of Professor Martin Fusek. Thanks to this, we knew the expectations that international companies and investors have when assessing scientific projects, and we knew what it takes to get them interested in a new technology. At the same time, we had already built up quite a wide network of contacts from previous activities. Thanks to all of this, we have managed to find and support many unique startups over the years, and we have helped many of them to attract important strategic partners. Within the incubator we have built an interesting portfolio of promising startups, in which we have already invested over 70 million (Czech) crowns in addition to other support. However, we felt from the beginning that this investment component of our business needed strengthening, if only to be able to attract more investors. That is why we decided to create a completely new entity that will specialise in investment activities. We we approached the EIF with our vision and they liked our idea. What followed was a rather difficult negotiation that resulted in the creation of the i&i Biotech Fund. If I may make light of it, our whole business resembles the well-known saying about the chicken and the egg. If there is a lack of investment, new projects do not emerge, but without interesting projects you will not get investor interest. I am therefore very pleased that we can now support the development of all elements of our innovatory ecosystem simultaneously. This gives the Fund the chance to access unique and well-proven investment opportunities that may not be available to other investors. Could you describe more about how the negotiations with the EIF went? It was a relatively long-term affair, with the first contacts and discussions taking place before the establishment of i&i Prague. The final phase of "courtship" lasted three years, with the last two being very intense. During that time we had to convince the EIF that we could invest their money well. We had to prove that we could identify innovative scientific startups with interesting investment potential, that we could manage the portfolio of these startups and increase their value over time. In addition, we had to go through many formal processes. We were scrutinized on the overall setup of the fund, the transparency of its management, the functionality of its control mechanisms and the ethics of investing. Last but not least, we had to meet the general criteria of the EIF – for example, that the support must be directed to small and medium-sized enterprises (SMEs). We are opening up to the world, which will also help Czech projects You have announced your first investment ventures. These are investments in the Austrian start-up Celeris Therapeutics, in the American company Dracen Pharmaceuticals and in the Czech-American technology start-up, Sampling Human. Although there is a significant Czech footprint in two of the three investments, it cannot be said that you are primarily focused on domestic startups. Is that right? Yes, it is. When we founded i&i Prague, we decided not to focus purely on the Czech Republic, but to open up to the world, figuratively speaking. We did the same when we set up the fund. The reason is simple – by cooperating with foreign partners for a long time, we learn and gain invaluable experience. We can then use this to select the most interesting Czech startups and help them become even better. This ultimately moves them forward and makes them competitive both in Europe and globally. When looking for investment opportunities, we therefore focus primarily on the Central European region, which we know well and where we have many good partners. However, in the event of an interesting offer, we are also ready to support projects that originate outside this geographical area. Thanks to the fact that we are creating a portfolio composed of unique Czech and foreign startups, we increase the chances of success for the whole fund and attract the attention of other foreign investors who are not yet familiar with our region. This is not to say that we don't want Czech projects. On the contrary, we will be happy for them. Our advantage is that, in addition to investment, we can also offer them intensive support from the i&i Prague incubator. What is your experience with the quality of Czech projects? How do they compare with foreign competitors? We know from experience that the ever-increasing quality of science in the Czech Republic gives the opportunity for unique ideas, inventions and technologies that are no worse than similar projects from the USA or Western Europe. The difference is mainly in the mindset of the people and the availability and quality of the supporting infrastructure, be it technology transfer centres, incubators or grant resources. I believe that, thanks to our Fund's approach, we will also gradually become fully integrated into the advanced European countries where we belong in the area of innovation and investment. Let us move on. As you yourself have already indicated, investment in the natural sciences does not have much of a tradition in the Czech Republic. Could you explain at least some of the specifics that this sector entails? Compared to other industries, investing in life sciences is more demanding in terms of knowledge and the amount of investment. We need to be able to assess the potential of new scientific discoveries, which entails the need to understand their nature and uniqueness. There is also a need for considerable flexibility, as the chosen technology is often developed towards an inappropriate application, so that the final use changes multiple times during development. The original business plan is constantly being significantly modified based on the results obtained. The better and more comprehensively you can understand, monitor or even direct the development of the entire project, the better your chances of success. Compared to other industries, there are also much stricter regulations. The other side of the coin is that there is less competition in this field within the EU, which gives a relatively small and new fund like i&i Biotech the chance to get involved in top European projects. As far as valuation is concerned, if you manage to overcome the considerable initial barriers with your technology and obtain the necessary certifications, the value of the project will increase rapidly and you can find a place on a global level. But it's not just about the money. Investing in innovative science projects advances human knowledge and new technologies help people. And it's exciting to be at the start of a journey that may one day end up bringing new drugs to market or introducing new diagnostic methods. Technology transfer? Like driving a car... Let's now turn to technology transfer, a concept that is intrinsically linked to your work. How would you answer the question of what it is for a layman? The whole process can be imagined, for example, like driving a car. At the beginning of the journey, i.e. during the initial research period, the scientist himself drives the car. The moment the project leaves the lab and develops into a functioning company, the driving becomes more and more challenging and the driving needs to be shared with professionals, experts and managers. The scientist then becomes much more of a navigator, showing where to turn, but the overall direction of travel must already be determined by market principles. During the journey, the crew is further expanded to include other passengers, such as economists, lawyers, patent experts and, of course, investors, who together ensure that the car does not run into a dead end, that any breakdowns are quickly repaired and that the car does not run out of petrol. Some of the passengers will only ride for a short distance, others will become a permanent part of the crew, but it is only through the effective cooperation of everyone involved that the challenges of this challenging journey can be overcome. It is important to have working relationships in place, otherwise the journey can end at the first minor puncture. It is the establishment of fair partnerships and sufficient trust between scientists, their parent institutions, managers, investors and companies that I believe is the main task of technology transfer offices. Everything else then runs almost by itself. What do you see as the biggest benefit that technology transfer brings? Technology transfer, including various forms of contract research, generates billions of (Czech) crowns for Czech science and universities. It is therefore an important pillar of funding that can only be further supported. Above all, it enables the transfer of scientific discoveries from the laboratory into practice. It is a long and challenging journey, during which it is necessary to ensure sufficient funding, legal protection and the correct commercial direction of the original scientific idea. The fact is that, without professional technology transfer, virtually no invention will achieve commercial success. This is also why many interesting results of science and research go unused and never help anyone. All major research institutions are gradually realising this, and technology transfer is becoming an increasingly important issue for the Academy of Sciences as well as for universities and other institutions. Why should a scientific discovery be commercially successful? I am referring to the relationship between technology transfer and basic research... Basic research pushes the boundaries of human knowledge, so the function is irreplaceable. Without it, no discoveries will be made, there will be nothing to transfer, and everything will probably only happen at the level of small innovations in companies. However, the aim of scientists should not only be to discover something new, but they should also think about whether they can help people with their discoveries. To do this, it is necessary to transfer successful ideas from scientific laboratories into practice, which is what technology transfer makes possible. Thus, technology transfer does not go against basic research, but instead constitutes a service needed to fulfil one of the primary functions of science, which is to improve the quality of human life. Scientist as businessman? The success of a startup depends not only on the idea itself or the willingness of investors to finance its development, but also on the skills of its managers. Where can you find such people? Finding experienced managers with the necessary scientific background is more than difficult in the Czech Republic, but it is not easy elsewhere in Europe either. It is a question of when we will be able to change this, because science entrepreneurship has almost no roots here. This is a structural problem that will take time to solve. We can start, for example, by including subjects in the study of science that introduce students to the start-up as an interesting perspective for their life development and give them the opportunity to experience such work, for example through internships. Thanks to their creativity and imagination, science students and young scientists are very well-placed to become successful managers. If we allow them to get a good feel for the workings of a start-up during their studies, I firmly believe that many of them would actually start their own companies in the future. Unfortunately, it still happens quite often that top Czech experts and scientists want to return after gaining further experience abroad, but we are not able to offer them favourable conditions to carry on further work in the Czech Republic. This problem could be partly solved by technology start-ups. By supporting them, we will not only enable the return of the investments we have made in the education of these people during their studies, but we will also start a positive spiral towards a knowledge-based economy with high added value. Fortunately, the necessary change is already gradually taking place, with the first successes appearing and more to follow. I am glad we are there. In conclusion, what would you wish Czech science on its way to further successes? I would wish it to finally get the necessary attention from politicians and other authorities. So that it does not have to defend its social need and its funding in such a complicated and repetitive way. Unfortunately, the current overblown bureaucracy and the eternal "presumption of guilt" often makes scientists more like bureaucrats, trying to comply with all the administrative requirements of grant and other agencies. In all this, they are left with relatively little time for scientific work itself, and it is difficult to carry out the more daring projects that can lead to groundbreaking discoveries. Despite all these obstacles, however, Czech science is growing and producing unique results. It seems to me, therefore, that it is about time that we were able to recognise the potential that Czech science offers to our economy. However, I would like us all, first and foremost, to stop underestimating ourselves unnecessarily in the Czech Republic. At least in the area of science, technology transfer and smart investment, I see no reason to do so. Author: Martin Kovalčík Published on www.vedavyzkum.cz , the interview can be found in Czech here .

CasInvent Pharma Raises €1.3 Million from KHAN-I and i&i Biotech Fund to Support the Development of New Casein Kinase 1 Inhibitors for the Treatment of Leukemias and Solid Tumors Prague, Czech Republic, September 13th, 2022. CasInvent Pharma, an early-stage drug discovery company developing small-molecule compounds with anticancer properties, has raised a follow-up investment round of €1.3 million provided by KHAN Technology Transfer Fund I (KHAN-I) and i&i Biotech Fund (i&i Bio). With this funding, CasInvent Pharma will be strengthening its portfolio of casein kinase inhibitors and progressing its lead compound to the development candidate status. The company CasInvent Pharma is developing proprietary, highly selective inhibitors of enzymes belonging to the casein kinase 1 (CK1) family, which play an important role in several disease-related processes, including the migration of leukemia cells into lymphoid organs. The small-molecule inhibitors are designed to target individual isoforms of CK1 and thereby selectively eradicate leukemic cells. The CasInvent inhibitors have shown promising effects on hard-to-treat leukemias, suggesting their potential use in diseases that currently have limited treatment options. Overall, approximately 500,000 new cases and more than 300,000 deaths due to leukemia were recorded worldwide in 2020. CasInvent Pharma will also explore the potential of its CK1 inhibitors for the treatment of other cancers, such as solid tumors. “We are confident that through the support of our investors, we will be able to advance our compounds faster into the clinic and to demonstrate the therapeutic anticancer effects of CK1 inhibition in patients. This step will render CasInvent attractive for larger pharma companies, as it will enable them to expand their portfolio with new compounds useful in single-agent as well as combination therapies,” says Vojtěch Helikar, CEO of CasInvent Pharma. “CK1 inhibition provides a novel mechanism of action in different cancer indications, which needs to be exploited in the clinic. We believe that our compounds have the potential to offer novel alternatives of cancer treatment for patients with a high unmet medical need,” adds Alexander Scheer, CSO of CasInvent Pharma. High quality of the research team and the strong support The company CasInvent Pharma was established in 2020 as a spin-off of Masaryk University (MU) in cooperation with the investment partner i&i Prague. “The investment of €1.3 million further confirms the quality of the scientific project that was created and developed for several years at Masaryk University. The establishment of the spin-off company CasInvent Pharma was thus a logical step to advance, and ultimately commercialize, these efforts. I am very pleased that the Technology Transfer Office of MU was part of such an important achievement,” says Radoslav Trautmann, Head of Technology Transfer Department, Masaryk University. “We are looking forward to our first investment in a Czech start-up and our first co-investment with the recently launched i&i Biotech Fund. From the beginning, we were impressed by the high quality of CasInvent’s research team and the strong support from Masaryk University and the biotech incubator i&i Prague to make this investment possible. With our deep experience in preclinical development of small molecules, we will be able to make valuable contributions to the design and achievement of the key R&D milestones. We look forward to working with Vojtěch, Alexander and the R&D team,” comment Michael Krebs and Peter Nussbaumer, managing partners of KHAN-I. CasInvent Pharma is i&i Bio’s most recent investment announced this year. It marks yet another successful cooperation with the biotech incubator i&i Prague, one of the main investors of i&i Bio. „We are excited to welcome another promising Czech project to our portfolio. The ability of this spin-off to convince renowned international investors confirms its ambition to be successful on a global scale. It is great to be part of this journey. We are also pleased to use our investment to support research that could help treat serious diseases such as leukemia in the future,“ says Ivan Vohlmuth, one of the partners of i&i Bio. Contact Martin Kovalčík, + 420 777 472 863, kovalcik@inibio.eu (for i&i Biotech Fund) Vojtěch Helikar, +420 728 995 850, helikar@casinvent.com (for CasInvent) Radoslav Trautmann, +420 605 824 519, trautmann@casinvent.com (for Masaryk University) Anne-Kathrin Klebl, +49231 97 42 70 29, pr@lead-discovery.de (for KHAN-I) About i&i Bio i&i Bio is a Luxembourg-based venture capital firm that invests in innovative European Life Sciences companies focused on drug discoveries, medical devices, diagnostics, and digital health. The Fund was created thanks to the cooperation of the biotech incubator i&i Prague and the European Investment Fund (see below). With over €45M under management, i&i Bio plans to invest in about 20 early-stage companies. i&i Bio is led by an experienced team of professionals with backgrounds in private equity, healthcare and venture capital supporting entrepreneurs on their journey to global success. Thanks to the close cooperation with the fund’s sponsor, the biotech academic incubator i&i Prague, i&i Bio is supporting and advancing transformative Central European technology companies. For more information visit www.inibio.eu . About European Investment Fund i&i Bio is supported by an investment from the EIF, with the support of: lnnovFin Equity, with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (EFSI) set up under the Investment Plan for Europe. The purpose of EFSI is to help support financing and implementing productive investments in the European Union and to ensure increased access to financing; and the Pan-European Guarantee Fund (EGF), implemented by the EIF with the financial support of the Participating Member States. The objective of EGF is to respond to the economic impact of the COVID-19 pandemic by ensuring that companies in the Participating Member States have sufficient short-term liquidity available to weather the crisis and are able to continue their growth and development in the medium to long-term. About KHAN-I KHAN Technology Transfer Fund I GmbH & Co KG (KHAN-I) is an early-stage life sciences venture fund with € 70 millions under management. Our mission is to create value through cooperative drug development partnerships with academic innovators in Europe. KHAN-I focuses on first-in-class therapies for attractive markets with a high unmet medical need. The fund is managed by Khanu Management GmbH, an experienced team of professionals with proven track records in early-stage drug development, academic spin-offs as well as pharma licensing and partnering. KHAN-I received an investment from the European Investment Fund (EIF) with support of InnovFin Equity, with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (“EFSI”) under the Investment Plan for Europe. KHAN-I is also supported by Austria Wirtschaftsservice GmbH (AWS with funds provided by the Austrian Federal Ministry for Digital and Economic Affairs and the Austrian Foundation for Research, Technology and Development), Max Planck Foundation and Thyssen’sche Handelsgesellschaft mbH. About Masaryk University Technology Transfer Office Masaryk University Technology Transfer Office is a specialised department of Masaryk University that helps to transfer knowledge and technology into practice. The Office supports the university's cooperation with the commercial sphere, the creation of spin-off companies and the successful commercialisation of university research.

LAM-X, a.s. won the 2020 EIT Health #MedTech Bootcamp final #Pitch Event i&i Prague supported start-up, LAM-X, a.s. , become a winner of the 2020 EIT Health #MedTech Bootcamp final #Pitch Event! After 5 intense, dense and focused full-time weeks in front of zoom, where the teams refined their business model, widened their network and worked on regulations and pitch skills, the 10 teams presented their projects to a curious, knowledgable jury: Jörg Trinkwalter, Olaf Weiner, Samuel Schuler and Stefan Fasbender – and LAM-X a.s. was evaluated as the most advanced! Congratulations!